Gene expression data of inflammatory mediators in apical periodontitis in 129 (wild type) and 5-lipoxygenase knockout mice
Thaise Mayumi Taira,
Vítor Luís Ribeiro,
Yuri Jivago Silva Ribeiro,
Raquel Assed Bezerra da Silva,
Léa Assed Bezerra da Silva,
Marília Pacífico Lucisano Politi,
Lúcia Helena Faccioli,
Francisco Wanderley Garcia Paula-Silva
Affiliations
Thaise Mayumi Taira
Department of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil
Vítor Luís Ribeiro
Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
Yuri Jivago Silva Ribeiro
Department of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil
Raquel Assed Bezerra da Silva
Department of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil
Léa Assed Bezerra da Silva
Department of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil
Marília Pacífico Lucisano Politi
Department of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil
Lúcia Helena Faccioli
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas da Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
Francisco Wanderley Garcia Paula-Silva
Department of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil; Corresponding author.
Apical periodontitis is an immune inflammatory response around periapical tissues as a result of pathogens invasion into the root canal. The host immunoinflammatory response could determine the progression of this disease, which involves the recruitment of immune cells, and the release of several cytokines in the lesion site. The 5-lipoxygenase pathway has been activated in some osteolytic diseases due to its capacity to interfere in the proliferation and differentiation of bone cells, including the osteoclasts. As mean to understand the inflammatory genes regulation in the apical periodontitis progression, we evaluated the network of 66 genes related to cytokines, chemokines and other inflammatory mediators and receptors in the wild-type (WT) and 5-lipoxygenase enzyme genetically deficient mice (KO). This article presents data not published but related to the research article “Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis” .
