New Diaryl-1,2,4-triazolo[3,4‑a]pyrimidine Hybrids as Selective COX-2/sEH Dual Inhibitors with Potent Analgesic/Anti-inflammatory and Cardioprotective Properties

• Lamya H. Al-Wahaibi,
• Mostafa H. Abdel-Rahman,
• Khaled El-Adl,
• Bahaa G. M. Youssif,
• Stefan Bräse,
• Salah A. Abdel-Aziz

Affiliations

Lamya H. Al-Wahaibi

Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Mostafa H. Abdel-Rahman

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy(Boys), Al-Azhar University, Assiut, Egypt

Khaled El-Adl

Department of Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, El Salam City, Egypt

Bahaa G. M. Youssif

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Stefan Bräse

Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, Karlsruhe, Germany

Salah A. Abdel-Aziz

Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Boys) Al-Azhar University, Assiut, Egypt