Disease Models & Mechanisms (Dec 2023)
Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia
- Leonard D. Kuhrt,
- Edyta Motta,
- Nirmeen Elmadany,
- Hannah Weidling,
- Raphaela Fritsche-Guenther,
- Ibrahim E. Efe,
- Olivia Cobb,
- Jit Chatterjee,
- Lucy G. Boggs,
- Marina Schnauß,
- Sebastian Diecke,
- Marcus Semtner,
- Corina Anastasaki,
- David H. Gutmann,
- Helmut Kettenmann
Affiliations
- Leonard D. Kuhrt
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Edyta Motta
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Nirmeen Elmadany
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Hannah Weidling
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Raphaela Fritsche-Guenther
- Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin, BIH Metabolomics Platform, 13353 Berlin, Germany
- Ibrahim E. Efe
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Olivia Cobb
- Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
- Jit Chatterjee
- Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
- Lucy G. Boggs
- Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
- Marina Schnauß
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Sebastian Diecke
- Technology Platform Pluripotent Stem Cells, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Marcus Semtner
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- Corina Anastasaki
- Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
- David H. Gutmann
- Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
- Helmut Kettenmann
- Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany
- DOI
- https://doi.org/10.1242/dmm.049861
- Journal volume & issue
-
Vol. 16,
no. 12
Abstract
No abstracts available.Keywords
- microglia
- neurofibromatosis 1
- human induced pluripotent stem cells
- purinergic receptors
- phagocytosis
- motility
