Nature Communications (Jan 2020)
Environmental arginine controls multinuclear giant cell metabolism and formation
- Julia S. Brunner,
- Loan Vulliard,
- Melanie Hofmann,
- Markus Kieler,
- Alexander Lercher,
- Andrea Vogel,
- Marion Russier,
- Johanna B. Brüggenthies,
- Martina Kerndl,
- Victoria Saferding,
- Birgit Niederreiter,
- Alexandra Junza,
- Annika Frauenstein,
- Carina Scholtysek,
- Yohei Mikami,
- Kristaps Klavins,
- Gerhard Krönke,
- Andreas Bergthaler,
- John J. O’Shea,
- Thomas Weichhart,
- Felix Meissner,
- Josef S. Smolen,
- Paul Cheng,
- Oscar Yanes,
- Jörg Menche,
- Peter J. Murray,
- Omar Sharif,
- Stephan Blüml,
- Gernot Schabbauer
Affiliations
- Julia S. Brunner
- Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna
- Loan Vulliard
- CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
- Melanie Hofmann
- Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna
- Markus Kieler
- Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna
- Alexander Lercher
- CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
- Andrea Vogel
- Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna
- Marion Russier
- Max Planck Institute of Biochemistry
- Johanna B. Brüggenthies
- Max Planck Institute of Biochemistry
- Martina Kerndl
- Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna
- Victoria Saferding
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Birgit Niederreiter
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Alexandra Junza
- CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM)
- Annika Frauenstein
- Max Planck Institute of Biochemistry
- Carina Scholtysek
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Yohei Mikami
- Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health
- Kristaps Klavins
- CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
- Gerhard Krönke
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Andreas Bergthaler
- CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
- John J. O’Shea
- Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health
- Thomas Weichhart
- Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna
- Felix Meissner
- Max Planck Institute of Biochemistry
- Josef S. Smolen
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Paul Cheng
- Bio Cancer Treatment International Ltd.
- Oscar Yanes
- CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM)
- Jörg Menche
- CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
- Peter J. Murray
- Max Planck Institute of Biochemistry
- Omar Sharif
- Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna
- Stephan Blüml
- Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis
- Gernot Schabbauer
- Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna
- DOI
- https://doi.org/10.1038/s41467-020-14285-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.
