Evaluating the Therapeutic Importance of Gold Nanoparticles Formed by the Biogenic Synthesis Route of Madhuca longifolia Reduction
Manikandan Dhayalan,
Sheikdawood Parveen,
Sathiyapriya Thirumalaisamy,
Faruq Mohammad,
Hamad A. Al-Lohedan,
Savaas Umar Mohammed Riyaz,
Rakshi Anuja Dinesh,
Jayant Giri,
Antony Stalin,
Gangireddy Rajasekhar Reddy,
Natarajan Anandakumar,
Saurav Mallik
Affiliations
Manikandan Dhayalan
Department of Prosthodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (Saveetha University) Chennai - 600 077, TamilNadu, India
Sheikdawood Parveen
Bio Inspired Material Research Laboratory, Dr. Mahalingam College of Engineering and Technology, Pollachi-642002, Tamil Nadu
Sathiyapriya Thirumalaisamy
Department of Chemistry, Coimbatore Marine College, Coimbatore-641032, India
Faruq Mohammad
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Hamad A. Al-Lohedan
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Savaas Umar Mohammed Riyaz
PG & Research Department of Biotechnology Islamiah College (Autonomous), Vaniyambadi - 635752, Tamil Nadu, India
Rakshi Anuja Dinesh
Faculty of Science, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia
Jayant Giri
Department of Mechanical Engineering, Yeshwantrao Chavan College of Engineering, Nagpur, Maharashtra, India
Antony Stalin
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054 China
Gangireddy Rajasekhar Reddy
NACL Industries Limited, R&D Center, Hyderabad, RR District - 509228, Telangana, India
Natarajan Anandakumar
Department of Education, The Gandhigram Rural Institute, Gandhigram, Dindigul-624302, India
Saurav Mallik
Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USA
Herbal plants have been used, in light of their responsiveness and wide availability, for the construction of a pioneering nanomaterial. In this study, a colloidal suspension of gold nanoparticles (GNPs) was synthesized from an extract of Madhuca longifolia (ML) using chloroauric acid. For biomedical applications, Madhuca longifolia (ML) was used as a bioreductant as well as a capping agent The formed ML-GNPs were analyzed using different analytical techniques, antioxidant assays, and thiazolyl blue formazan assay against A549 cell lines to evaluate clinical relevance. They were further evaluated for their influence on antimicrobial activity using a disc diffusion test against two different microorganisms, Proteus vulgaris and Micrococcus luteus. The ML-GNPs produced had good antioxidant, antibacterial, and anticancer activities. The conformation of the XRD spectra with prominent characteristic planes was indexed to the face-centered cubic (fcc)-structured GNPs. Surface morphology analysis was used to determine the particle size of the GNPs. Fourier transform infrared spectra of the samples were used to determine the analogs for strong H bonding. The MIC values of biogenic GNPs against both strains of Proteus vulgaris and Micrococcus luteus was calculated as 0.29 and 0.96 g/mL, respectively, and triclosan was considered as 0.4 and 2 g/mL, respectively. The findings of this study will be beneficial for future studies of the therapeutic potential of ML-GNPs. Actively, ML-GNPs can be a capable material for formulating nanomedicines after subsequent clinical experiments.
