Characterization of fecal microbiota in cervical cancer patients associated with tumor stage and prognosis

Lei Chang; Luojie Qiu; Ningjing Lei; Junying Zhou; Ruixia Guo; Feng Gao; Feng Gao; Shiliang Dong; Mengyu Chen; Fengling Wu; Bo Qin

doi:10.3389/fcimb.2023.1145950

Frontiers in Cellular and Infection Microbiology (Feb 2023)

Characterization of fecal microbiota in cervical cancer patients associated with tumor stage and prognosis

Lei Chang,
Luojie Qiu,
Ningjing Lei,
Junying Zhou,
Ruixia Guo,
Feng Gao,
Feng Gao,
Shiliang Dong,
Mengyu Chen,
Fengling Wu,
Bo Qin

Affiliations

Lei Chang: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China
Luojie Qiu: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China
Ningjing Lei: School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China
Junying Zhou: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China
Ruixia Guo: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China
Feng Gao: Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China
Feng Gao: Henan Engineering Technology Research Center for Accurate Diagnosis Neuroimmunity, Zhengzhou, Henan, China
Shiliang Dong: Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Mengyu Chen: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China
Fengling Wu: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China
Bo Qin: Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

DOI: https://doi.org/10.3389/fcimb.2023.1145950
Journal volume & issue: Vol. 13

Abstract

Read online

Cervical cancer (CC) is the fourth most frequent malignancy among women worldwide, and its prevention and treatment are evolving rapidly. The gut microbiota has been reported to play a crucial role both in the preservation of homeostasis and the development of cervical cancer. In this study, we collected fecal samples to investigate the microbial signatures in cervical cancer patients compared with healthy controls using 16S rRNA sequencing analysis and metagenomic next-generation sequencing (mNGS) testing. Our findings demonstrated a substantial difference in the gut microbiota composition of cervical cancer patients and healthy controls. The disease and stage were most significantly negatively correlated with Ruminococcus 2, which might be considered a potential clinically relevant biomarker. Functions of differential microbiomes were also analyzed, indicating significant differences in metabolisms and biosynthesis between the two groups. These findings demonstrate that patients with cervical cancer have certain species of gut microbiota that are exclusive to them and particular species have the potential to be used in the prognosis of cervical cancer.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

About the journal

Abstract

Keywords