Journal of Islamic International Medical College (Dec 2021)
Association of N-Terminal Pro Brain Natriuretic Peptide with Ventricular Ectopy
Abstract
Objective: This study aimed to determine the association of premature ventricular contractions burden of less than 20% with NT-pro BNP levels in patients with preserved left ventricular function. Study Design: Case control analytical study. Place and Duration of Study: It was conducted in physiology department of Islamic International Medical College (IIMC) in collaboration with Armed Forces Institute of Cardiology (AFIC) during the period of 18 April 2016 to 20 March 2018. Materials and Methods: The study comprised a total of fifty participants which included 40 diagnosed patients of premature ventricular contractions (PVCs) and 10 healthy subjects (with no PVCs). PVCs burden was calculated by Holter monitoring report and echocardiography was done to determine left ventricular ejection fraction. Patients with burden>20% and Ejection fraction<50% were excluded. In all these patients NT-proBNP levels were measured and statistical analysis was done using SPSS version 25. Student's t-test and Pearson correlation tests were applied to see its association with PVCs burden. Results: Ventricular ectopic burden<20% has NT-proBNP higher than controls but the increase is insignificant with p value of 0.056. Pearson correlation test showed no correlation of Premature ventricular contractions <20% with NT-pro BNP levels with r value of 0.1. Conclusion: It can be concluded that the patients with PVCs burden less than 20% has no correlation with NTpro BNP so they should not be considered as high risk patients.
