Research progress of cuproptosis in the treatment and prognosis of oral squamous cell carcinoma

Abstract

Oral squamous cell carcinoma(OSCC)is a malignant tumor with a high mortality rate, which is characterized by late diagnosis, high recurrence and metastasis rates, and poor prognosis. Cuproptosis, as a novel mode of cupric induced cell death, can inhibit the growth and proliferation of cancer cells by activating related pathways, which provides a new insight into the treatment of OSCC. This review aims to systematically introduce the mechanism of cuproptosis occurrence and development, as well as the research progress of cuproptosis in the prognosis of OSCC treatment. It provides new ideas and methods for clinical treatment.

Keywords

• |oral squamous cell carcinoma|cuproptosis|ferredoxin 1|protein lipids|copper chelates|lncrna|tricarboxylic acid cycle