Communications Biology (Mar 2022)
Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
- Lei Zhu,
- Rob W. van der Pluijm,
- Michal Kucharski,
- Sourav Nayak,
- Jaishree Tripathi,
- Nicholas J. White,
- Nicholas P. J. Day,
- Abul Faiz,
- Aung Pyae Phyo,
- Chanaki Amaratunga,
- Dysoley Lek,
- Elizabeth A. Ashley,
- François Nosten,
- Frank Smithuis,
- Hagai Ginsburg,
- Lorenz von Seidlein,
- Khin Lin,
- Mallika Imwong,
- Kesinee Chotivanich,
- Mayfong Mayxay,
- Mehul Dhorda,
- Hoang Chau Nguyen,
- Thuy Nhien Thanh Nguyen,
- Olivo Miotto,
- Paul N. Newton,
- Podjanee Jittamala,
- Rupam Tripura,
- Sasithon Pukrittayakamee,
- Thomas J. Peto,
- Tran Tinh Hien,
- Arjen M. Dondorp,
- Zbynek Bozdech
Affiliations
- Lei Zhu
- School of Biological Sciences, Nanyang Technological University
- Rob W. van der Pluijm
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Michal Kucharski
- School of Biological Sciences, Nanyang Technological University
- Sourav Nayak
- School of Biological Sciences, Nanyang Technological University
- Jaishree Tripathi
- School of Biological Sciences, Nanyang Technological University
- Nicholas J. White
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Nicholas P. J. Day
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Abul Faiz
- Ramu Upazila Health Complex
- Aung Pyae Phyo
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Chanaki Amaratunga
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Dysoley Lek
- National Centre for Parasitology, Entomology and Malaria Control
- Elizabeth A. Ashley
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- François Nosten
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Frank Smithuis
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Hagai Ginsburg
- The Alexander Silberman Institute of Life Science, Hebrew University of Jerusalem
- Lorenz von Seidlein
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Khin Lin
- Department of Medical Research
- Mallika Imwong
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Kesinee Chotivanich
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Mayfong Mayxay
- Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
- Mehul Dhorda
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Hoang Chau Nguyen
- Oxford University Clinical Research Unit, Hospital for Tropical Diseases
- Thuy Nhien Thanh Nguyen
- Oxford University Clinical Research Unit, Hospital for Tropical Diseases
- Olivo Miotto
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Paul N. Newton
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Podjanee Jittamala
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Rupam Tripura
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Sasithon Pukrittayakamee
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Thomas J. Peto
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Tran Tinh Hien
- Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University
- Arjen M. Dondorp
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Zbynek Bozdech
- School of Biological Sciences, Nanyang Technological University
- DOI
- https://doi.org/10.1038/s42003-022-03215-0
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Transcriptomic analysis of isolates from the malaria parasite (Plasmodium falciparum) in the Greater Mekong Subregion of Southeast Asia identifies gene expression patterns that are correlated with resistance to a common anti-malaria drug, artemisinin.
