Cancers (Dec 2022)
Gastric-Type Adenocarcinoma of the Uterine Cervix Associated with Poor Response to Definitive Radiotherapy
- Airi Kuruma,
- Michiko Kodama,
- Yumiko Hori,
- Kazuaki Sato,
- Makoto Fujii,
- Fumiaki Isohashi,
- Ai Miyoshi,
- Seiji Mabuchi,
- Akira Setoguchi,
- Hiroko Shimura,
- Takeshi Goto,
- Aska Toda,
- Satoshi Nakagawa,
- Yasuto Kinose,
- Tsuyoshi Takiuchi,
- Eiji Kobayashi,
- Kae Hashimoto,
- Yutaka Ueda,
- Kenjiro Sawada,
- Eiichi Morii,
- Tadashi Kimura
Affiliations
- Airi Kuruma
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Michiko Kodama
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Yumiko Hori
- Department of Central Laboratory and Surgical Pathology, National Hospital Organization Osaka National Hospital, 2-1-4, Hoenzaka, Chuo-Ku, Osaka City 5400006, Osaka, Japan
- Kazuaki Sato
- Department of Pathology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osaka, Japan
- Makoto Fujii
- Division of Health Science, Osaka University Graduate School of Medicine, 1-7, Yamadaoka, Suita City 5650871, Osaka, Japan
- Fumiaki Isohashi
- Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osaka, Japan
- Ai Miyoshi
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Seiji Mabuchi
- Department of Gynecology, Osaka International Cancer Institute, 3-1-69, Otemae 5418567, Osaka, Japan
- Akira Setoguchi
- Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osaka, Japan
- Hiroko Shimura
- Department of Obstetrics and Gynecology, Nippon Life Hospital, 2-1-54, Enokojima, Nishi-Ku, Osaka City 5500006, Osaka, Japan
- Takeshi Goto
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Aska Toda
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Satoshi Nakagawa
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Yasuto Kinose
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Tsuyoshi Takiuchi
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Eiji Kobayashi
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Kae Hashimoto
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Yutaka Ueda
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Kenjiro Sawada
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- Eiichi Morii
- Department of Pathology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osaka, Japan
- Tadashi Kimura
- Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City 5650871, Osak, Japan
- DOI
- https://doi.org/10.3390/cancers15010170
- Journal volume & issue
-
Vol. 15,
no. 1
p. 170
Abstract
We aimed to evaluate the response to definitive radiotherapy (RT) for cervical cancer based on histological subtypes and investigate prognostic factors in adenocarcinoma (AC). Of the 396 patients treated with definitive RT between January, 2010 and July, 2020, 327 patients met the inclusion criteria, including 275 with squamous cell carcinoma (SCC) and 52 with AC restaged based on the 2018 International Federation of Gynecology and Obstetrics staging system. Patient characteristics, response to RT, and prognoses of SCC and AC were evaluated. The complete response (CR) rates were 92.4% and 53.8% for SCC and AC, respectively (p p p p p < 0.05). Definitive RT for cervical cancer was significantly less effective for AC than for SCC. GAS was the only independent prognostic factor associated with non-CR in AC.
Keywords
