Research Advances in the Mechanism of Invasion and Metastasis of Circulating Tumor Cells in Lung Cancer

Abstract

In recent years, with the emergence of liquid biopsies, circulating tumor cells (CTCs) demonstrated significant value in the early diagnosis of patients with cancer, curative effect evaluation and prognosis evaluation. CTCs are the main cause of tumor metastasis, which indicates the poor prognosis of patients. Therefore, it is particularly important to elucidate the mechanism of CTC's generation, how to entry into circulatory system and immune escape. At present, accurate diagnosis and treatment has become an important direction to improve the prognosis of lung cancer patients. CTC for lung cancer is expected to provide a strong theoretical basis and important methods for accurate diagnosis and treatment of lung cancer. This paper reviews the latest research progress on the above hot issues.

Keywords

• lung neoplasms
• circulating tumor cells
• generative mechanism
• molecular maker
• immune escape
• detection method
• clinical application