<i>BDP1</i> Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study
Xiaoqing Li,
Lan Sun,
Andres Stucky,
Lingli Tu,
Jin Cai,
Xuelian Chen,
Zhongjun Wu,
Xuhong Jiang,
Shengwen Calvin Li
Affiliations
Xiaoqing Li
Department of Oncology, the People’s Hospital of Bishan District, Chongqing 402760, China
Lan Sun
Department of Oncology, the People’s Hospital of Bishan District, Chongqing 402760, China
Andres Stucky
Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Lingli Tu
Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Jin Cai
Department of Oral and Maxillofacial Surgery, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, China
Xuelian Chen
Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Zhongjun Wu
Department of Oncology, the People’s Hospital of Bishan District, Chongqing 402760, China
Xuhong Jiang
Department of Health Management, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, China
Shengwen Calvin Li
Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, CHOC Children’s Research Institute, Children’s Hospital of Orange County (CHOC), 1201 West La Veta Ave, Orange, CA 92868-3874, USA
Background: Neuroblastoma (N.B.) is the most common tumor in children. The gene BDP1 (B Double Prime 1) plays a role in cancers but is less known in N.B. Thus, we conducted this study to investigate the value of BDP1 mutations in N.B. prognosis. Methods: A dataset of 121 NB patients from the Cancer Genome Atlas database was used to analyze BDP1 gene mutations by RNA sequencing. Kaplan-Meier estimates were performed for overall survival (O.S.) analysis on BDP1 variants, and Cox’s proportional hazards regression model was used for multivariate analysis. Results: In 121 NB patients, we identified two variants of BDP1 associated with N.B., located at chr5:71511131 and chr5:71510884. The prevalence of these BDP1 variants, I1264M and V1347M, was 52.9% (64/121) and 45.5% (55/121), respectively. O.S. analysis showed a significant difference between subgroups with or without BDP1 variants (p BDP1ariants were independent prognostic variables in N.B. (p BDP1 variants are associated with significantly improved clinical outcomes in N.B., thus providing clinicians with a new tool.
