E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

Cecilia Grimaldi; Isabel Schumacher; Aleix Boquet-Pujadas; Katsiaryna Tarbashevich; Bart Eduard Vos; Jan Bandemer; Jan Schick; Anne Aalto; Jean-Christophe Olivo-Marin; Timo Betz; Erez Raz

doi:10.1038/s41467-020-19114-z

Nature Communications (Oct 2020)

E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

Cecilia Grimaldi,
Isabel Schumacher,
Aleix Boquet-Pujadas,
Katsiaryna Tarbashevich,
Bart Eduard Vos,
Jan Bandemer,
Jan Schick,
Anne Aalto,
Jean-Christophe Olivo-Marin,
Timo Betz,
Erez Raz

Affiliations

Cecilia Grimaldi: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Isabel Schumacher: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Aleix Boquet-Pujadas: Institut Pasteur, Bioimage Analysis Unit
Katsiaryna Tarbashevich: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Bart Eduard Vos: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Jan Bandemer: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Jan Schick: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Anne Aalto: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Jean-Christophe Olivo-Marin: Institut Pasteur, Bioimage Analysis Unit
Timo Betz: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Erez Raz: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster

DOI: https://doi.org/10.1038/s41467-020-19114-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The arrival of migratory cells at their targets relies on following precise routes within tissues. Here the authors demonstrate that the cell adhesion molecule E-cadherin can control the path of cell migration by confining the site where bleb-type protrusions form within the cell front.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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