Synthesis of New Zirconium Magnetic Nanocomposite as a Bioactive Agent and Green Catalyst in the Four-Component Synthesis of a Novel Multi-Ring Compound Containing Pyrazole Derivatives
Mohammed Asiri,
Ahmed Ghalib Abdulsalam,
Mustafa Kahtan,
Fahad Alsaikhan,
Issa Farhan,
Dhameer A. Mutlak,
Salema K. Hadrawi,
Muath Suliman,
Ritamaria Di Lorenzo,
Sonia Laneri
Affiliations
Mohammed Asiri
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia
Ahmed Ghalib Abdulsalam
Department of Pharmacy, Al-Noor University College, Bartella 46476, Iraq
Mustafa Kahtan
Medical Technical College, Al-Farahidi University, Baghdad 10011, Iraq
Fahad Alsaikhan
College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia
Issa Farhan
Medical Physics Department, Al-Mustaqbal University College, Babylon 51001, Iraq
Dhameer A. Mutlak
AL-Nisour University College, Baghdad 10001, Iraq
Salema K. Hadrawi
Refrigeration and Air-Conditioning Technical Engineering Department, College of Technical Engineering, The Islamic University, Najaf 54001, Iraq
Muath Suliman
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia
Ritamaria Di Lorenzo
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49-80131 Naples, Italy
Sonia Laneri
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49-80131 Naples, Italy
New nanocomposites containing zirconium were synthesized using microwave irradiation. Their structure was confirmed by vibrating sample magnetometer (VSM) curves, X-ray diffraction (XRD) patterns, scanning electron microscope (SEM) and transmission electron microscopy (TEM) images, Fourier transform infrared spectroscopy (FT-IR), and Brunauer–Emmett–Teller (BET) N2 adsorption/desorption isotherms. After the structure confirmation of the zirconium magnetic nanocomposite, the catalytic properties in the synthesis of pyrazole derivatives were investigated. Next, the biological activities of the zirconium magnetic nanocomposite, such as the antibacterial and antifungal activities, were investigated. The research results showed that the zirconium magnetic nanocomposite has high catalytic properties and can be used as a magnetic nanocatalyst for synthesizing heterocyclic compounds such as pyrazole derivatives in addition to having high biological properties. The unique properties of the nanoparticles can be attributed to their synthesis method and microwave radiation.
