Emerging Infectious Diseases (Feb 2017)

Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle

  • Hiroyuki Okada,
  • Yoshifumi Iwamaru,
  • Morikazu Imamura,
  • Kohtaro Miyazawa,
  • Yuichi Matsuura,
  • Kentaro Masujin,
  • Yuichi Murayama,
  • Takashi Yokoyama

DOI
https://doi.org/10.3201/eid2302.161416
Journal volume & issue
Vol. 23, no. 2
pp. 284 – 287

Abstract

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To determine oral transmissibility of the L-type bovine spongiform encephalopathy (BSE) prion, we orally inoculated 16 calves with brain homogenates of the agent. Only 1 animal, given a high dose, showed signs and died at 88 months. These results suggest low risk for oral transmission of the L-BSE agent among cattle.

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