Medication history-wide association studies for pharmacovigilance of pregnant patients

Anup P. Challa; Xinnan Niu; Etoi A. Garrison; Sara L. Van Driest; Lisa M. Bastarache; Ethan S. Lippmann; Robert R. Lavieri; Jeffery A. Goldstein; David M. Aronoff

doi:10.1038/s43856-022-00181-w

Communications Medicine (Sep 2022)

Medication history-wide association studies for pharmacovigilance of pregnant patients

Anup P. Challa,
Xinnan Niu,
Etoi A. Garrison,
Sara L. Van Driest,
Lisa M. Bastarache,
Ethan S. Lippmann,
Robert R. Lavieri,
Jeffery A. Goldstein,
David M. Aronoff

Affiliations

Anup P. Challa: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center
Xinnan Niu: Department of Biomedical Informatics, Vanderbilt University
Etoi A. Garrison: Department of Obstetrics and Gynecology, Vanderbilt University Medical Center
Sara L. Van Driest: Department of Pediatrics, Vanderbilt University Medical Center
Lisa M. Bastarache: Department of Biomedical Informatics, Vanderbilt University
Ethan S. Lippmann: Department of Chemical and Biomolecular Engineering, Vanderbilt University
Robert R. Lavieri: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center
Jeffery A. Goldstein: Department of Pathology, Northwestern University
David M. Aronoff: Department of Obstetrics and Gynecology, Vanderbilt University Medical Center

DOI: https://doi.org/10.1038/s43856-022-00181-w
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 10

Abstract

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Challa et al. used 2.8 million electronic health records for proactive pharmacovigilance program development, by rapidly generating and validating hypotheses between medication use during pregnancy and neonatal neurodevelopmental defects. They identify five drug classes for which deeper safety signal evaluation may improve product marketing.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

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