Frontiers in Endocrinology (Nov 2014)
EVIDENCE FOR A 12 kDa "CARRIER PROTEIN" FOR NATRIURETIC HORMONE
Abstract
The search for the elusive natriuretic hormone continues. In this review evidence is presented that isolating the carrier protein for natriuretic hormone is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 daltons. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17 kDa protein that can be split between a 14 kDa protein (the presumptive proANF) and the 3 kDa ANF.
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