Microarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning
Zhiqian Yu,
Mai Sakai,
Hotaka Fukushima,
Chiaki Ono,
Yoshie Kikuchi,
Ryuta Koyama,
Ko Matsui,
Tomoyuki Furuyashiki,
Satoshi Kida,
Hiroaki Tomita
Affiliations
Zhiqian Yu
Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Corresponding author: Zhiqian Yu, Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Japan, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.
Mai Sakai
Department of Psychiatry Nursing, Tohoku University, Sendai, Japan
Hotaka Fukushima
Department of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Japan
Chiaki Ono
Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Japan
Yoshie Kikuchi
Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Japan
Ryuta Koyama
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Ko Matsui
Super-network Brain Physiology, Tohoku University Graduate School of Life Sciences, Sendai, Japan
Tomoyuki Furuyashiki
Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe, Japan
Satoshi Kida
Department of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Japan; Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
Hiroaki Tomita
Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Department of Disaster Psychiatry, International Research Institute for Disaster Science, Tohoku University, Sendai, Japan
The transcription profile of microglia related to fear conditioning remains unclear. Here, we used Illumina MouseWG-6v2 microarrays to investigate the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6 J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the training context without footshock for three different durations 24 h later: 0 min (FS0), 3 min (FS3), or 30 min (FS30). Whole brain microglia and peripheral monocytes were prepared 24 h after re-exposure using a neural tissue dissociation kit, including non-footshock controls for two re-exposure durations (Con3 and Con30). The data can be valuable for researchers interested in glial cells and neurotransmission studies and are related to the research article “Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia”.
