Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Jia Cao; Jinghua Peng; Hongying An; Qiyi He; Tatiana Boronina; Shaodong Guo; Morris F. White; Philip A. Cole; Ling He

doi:10.1038/s41467-017-00163-w

Nature Communications (Jul 2017)

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Jia Cao,
Jinghua Peng,
Hongying An,
Qiyi He,
Tatiana Boronina,
Shaodong Guo,
Morris F. White,
Philip A. Cole,
Ling He

Affiliations

Jia Cao: Division of Metabolism, Department of Pediatrics, Johns Hopkins University School of Medicine
Jinghua Peng: Division of Metabolism, Department of Pediatrics, Johns Hopkins University School of Medicine
Hongying An: Division of Metabolism, Department of Pediatrics, Johns Hopkins University School of Medicine
Qiyi He: Department of Neuroscience, Brown University
Tatiana Boronina: Departments of Biochemistry, Johns Hopkins University School of Medicine
Shaodong Guo: Department of Nutrition and Food Science, Texas A&M University
Morris F. White: Division of Endocrinology, Boston Children’s Hospital, Harvard University
Philip A. Cole: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine
Ling He: Division of Metabolism, Department of Pediatrics, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-017-00163-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescued by pharmacological inhibition of P300.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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