Two Novel Hepatocellular Carcinoma Cycle Inhibitory Cyclodepsipeptides from a Hydrothermal Vent Crab-Associated Fungus Aspergillus clavatus C2WU

Wei Jiang; Panpan Ye; Chen-Tung Arthur Chen; Kuiwu Wang; Pengyuan Liu; Shan He; Xiaodan Wu; Lishe Gan; Ying Ye; Bin Wu

doi:10.3390/md11124761

Marine Drugs (Dec 2013)

Two Novel Hepatocellular Carcinoma Cycle Inhibitory Cyclodepsipeptides from a Hydrothermal Vent Crab-Associated Fungus Aspergillus clavatus C2WU

Wei Jiang,
Panpan Ye,
Chen-Tung Arthur Chen,
Kuiwu Wang,
Pengyuan Liu,
Shan He,
Xiaodan Wu,
Lishe Gan,
Ying Ye,
Bin Wu

Affiliations

Wei Jiang: Ocean College, Zhejiang University, Hangzhou 310058, China
Panpan Ye: Eye center, the second affiliated hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
Chen-Tung Arthur Chen: Ocean College, Zhejiang University, Hangzhou 310058, China
Kuiwu Wang: Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310058, China
Pengyuan Liu: Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701, OH, USA
Shan He: Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education, Ningbo 315211, China
Xiaodan Wu: Ocean College, Zhejiang University, Hangzhou 310058, China
Lishe Gan: Ocean College, Zhejiang University, Hangzhou 310058, China
Ying Ye: Ocean College, Zhejiang University, Hangzhou 310058, China
Bin Wu: Ocean College, Zhejiang University, Hangzhou 310058, China

DOI: https://doi.org/10.3390/md11124761
Journal volume & issue: Vol. 11, no. 12
pp. 4761 – 4772

Abstract

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Two novel cyclodepsipeptides containing an unusual anthranilic acid dimer and a d-phenyllactic acid residues, clavatustides A (1) and B (2), were identified from cultured mycelia and broth of Aspergillus clavatus C2WU isolated from Xenograpsus testudinatus, which lives at extreme, toxic habitat around the sulphur-rich hydrothermal vents in Taiwan Kueishantao. This is the first example of cyclopeptides containing an anthranilic acid dimer in natural products, and the first report of microbial secondary metabolites from the hydrothermal vent crab. Clavatustides A (1) and B (2) suppressed the proliferation of hepatocellular carcinoma (HCC) cell lines (HepG2, SMMC-7721 and Bel-7402) in a dose-dependent manner, and induced an accumulation of HepG2 cells in G1 phase and reduction of cells in S phase.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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