Frontiers in Aging Neuroscience (Jul 2018)
Low Concentrations of Caffeine and Its Analogs Extend the Lifespan of Caenorhabditis elegans by Modulating IGF-1-Like Pathway
- Xiaocui Du,
- Xiaocui Du,
- Xiaocui Du,
- Yun Guan,
- Yun Guan,
- Yun Guan,
- Qin Huang,
- Qin Huang,
- Qin Huang,
- Ming Lv,
- Ming Lv,
- Ming Lv,
- Xiaofang He,
- Xiaofang He,
- Xiaofang He,
- Liang Yan,
- Shuhei Hayashi,
- Shuhei Hayashi,
- Chongye Fang,
- Chongye Fang,
- Chongye Fang,
- Chongye Fang,
- Chongye Fang,
- Xuanjun Wang,
- Xuanjun Wang,
- Xuanjun Wang,
- Xuanjun Wang,
- Xuanjun Wang,
- Jun Sheng,
- Jun Sheng,
- Jun Sheng,
- Jun Sheng
Affiliations
- Xiaocui Du
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Xiaocui Du
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Xiaocui Du
- College of Food Science and Technology, Yunnan Agricultural University, Kunming, China
- Yun Guan
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Yun Guan
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Yun Guan
- College of Food Science and Technology, Yunnan Agricultural University, Kunming, China
- Qin Huang
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Qin Huang
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Qin Huang
- College of Food Science and Technology, Yunnan Agricultural University, Kunming, China
- Ming Lv
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Ming Lv
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Ming Lv
- College of Food Science and Technology, Yunnan Agricultural University, Kunming, China
- Xiaofang He
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Xiaofang He
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Xiaofang He
- College of Food Science and Technology, Yunnan Agricultural University, Kunming, China
- Liang Yan
- Pu’er Institute of Pu-erh Tea, Pu’er, China
- Shuhei Hayashi
- Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan
- Shuhei Hayashi
- China-Japan Joint Center for Bioresource Research and Development, Yunnan Agricultural University, Kunming, China
- Chongye Fang
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Chongye Fang
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Chongye Fang
- China-Japan Joint Center for Bioresource Research and Development, Yunnan Agricultural University, Kunming, China
- Chongye Fang
- College of Veterinary Medicine, Yunnan Agricultural University, Kunming, China
- Chongye Fang
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, China
- Xuanjun Wang
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Xuanjun Wang
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Xuanjun Wang
- China-Japan Joint Center for Bioresource Research and Development, Yunnan Agricultural University, Kunming, China
- Xuanjun Wang
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, China
- Xuanjun Wang
- College of Science, Yunnan Agricultural University, Kunming, China
- Jun Sheng
- Key Laboratory of Pu-erh Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China
- Jun Sheng
- Tea Research Center of Yunnan, Yunnan Academy of Agricultural Sciences, Kunming, China
- Jun Sheng
- China-Japan Joint Center for Bioresource Research and Development, Yunnan Agricultural University, Kunming, China
- Jun Sheng
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, China
- DOI
- https://doi.org/10.3389/fnagi.2018.00211
- Journal volume & issue
-
Vol. 10
Abstract
Caffeine has been reported to delay aging and protect aging-associated disorders in Caenorhabditis elegans. However, the effects of low concentration of caffeine and its analogs on lifespan are currently missing. Herein, we report that at much lower concentrations (as low as 10 μg/ml), caffeine extended the lifespan of C. elegans without affecting food intake and reproduction. The effect of caffeine was dependent on IGF-1-like pathway, although the insulin receptor homolog, daf-2 allele, e1371, was dispensable. Four caffeine analogs, 1-methylxanthine, 7-methylxanthine, 1,3-dimethylxanthine, and 1,7-dimethylxanthine, also extended lifespan, whereas 3-methylxanthine and 3,7-dimethylxanthine did not exhibit lifespan-extending activity.
Keywords
