Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity

Muaz Nik Rushdi; Victor Pan; Kaitao Li; Hyun-Kyu Choi; Stefano Travaglino; Jinsung Hong; Fletcher Griffitts; Pragati Agnihotri; Roy A. Mariuzza; Yonggang Ke; Cheng Zhu

doi:10.1038/s41467-022-34587-w

Nature Communications (Nov 2022)

Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity

Muaz Nik Rushdi,
Victor Pan,
Kaitao Li,
Hyun-Kyu Choi,
Stefano Travaglino,
Jinsung Hong,
Fletcher Griffitts,
Pragati Agnihotri,
Roy A. Mariuzza,
Yonggang Ke,
Cheng Zhu

Affiliations

Muaz Nik Rushdi: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Victor Pan: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Kaitao Li: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Hyun-Kyu Choi: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Stefano Travaglino: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Jinsung Hong: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Fletcher Griffitts: Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology
Pragati Agnihotri: W. M. Keck Laboratory for Structural Biology, Institute for Bioscience and Biotechnology Research, University of Maryland
Roy A. Mariuzza: W. M. Keck Laboratory for Structural Biology, Institute for Bioscience and Biotechnology Research, University of Maryland
Yonggang Ke: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Cheng Zhu: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

DOI: https://doi.org/10.1038/s41467-022-34587-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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It is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding of TCR and CD4 to the MHC-peptide complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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