Cytokine profiles in early rejection following OKT3 treatment in liver transplant patients

Sasan  Roayaie; Patricia A. Sheiner; Sukru  Emre; Steven  Guy; Myron E. Schwartz; Peter  Boros; Charles M. Miller

doi:10.1080/09629350020002877

Mediators of Inflammation (Jan 2000)

Cytokine profiles in early rejection following OKT3 treatment in liver transplant patients

Sasan Roayaie,
Patricia A. Sheiner,
Sukru Emre,
Steven Guy,
Myron E. Schwartz,
Peter Boros,
Charles M. Miller

Affiliations

Sasan Roayaie: The Recanati/Miller Transplantation Institute, The Mount Sinai School of Medicine, Box 1504, One Gustave L. Levy Place, New York 10029, NY, USA
Patricia A. Sheiner: The Recanati/Miller Transplantation Institute, The Mount Sinai School of Medicine, Box 1504, One Gustave L. Levy Place, New York 10029, NY, USA
Sukru Emre: The Recanati/Miller Transplantation Institute, The Mount Sinai School of Medicine, Box 1504, One Gustave L. Levy Place, New York 10029, NY, USA
Steven Guy: The Recanati/Miller Transplantation Institute, The Mount Sinai School of Medicine, Box 1504, One Gustave L. Levy Place, New York 10029, NY, USA
Myron E. Schwartz: The Recanati/Miller Transplantation Institute, The Mount Sinai School of Medicine, Box 1504, One Gustave L. Levy Place, New York 10029, NY, USA
Peter Boros: The Recanati/Miller Transplantation Institute, The Mount Sinai School of Medicine, Box 1504, One Gustave L. Levy Place, New York 10029, NY, USA
Charles M. Miller: The Recanati/Miller Transplantation Institute, The Mount Sinai School of Medicine, Box 1504, One Gustave L. Levy Place, New York 10029, NY, USA

DOI: https://doi.org/10.1080/09629350020002877
Journal volume & issue: Vol. 9, no. 3-4
pp. 141 – 146

Abstract

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OKT3, a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFα and IL1β. Liver recipients who experience rejection within 3 weeks after transplantation with OKT3 prophylaxis recover their T cells by postoperative day 10 despite complete initial clearance.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/mi/

About the journal