Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons

Yu-Ting Lin; Chien-Chung Chen; Chiung-Chun Huang; Katsuhiko Nishimori; Kuei-Sen Hsu

doi:10.1038/s41467-017-00675-5

Nature Communications (Sep 2017)

Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons

Yu-Ting Lin,
Chien-Chung Chen,
Chiung-Chun Huang,
Katsuhiko Nishimori,
Kuei-Sen Hsu

Affiliations

Yu-Ting Lin: Department of Pharmacology, College of Medicine, National Cheng Kung University
Chien-Chung Chen: Department of Pharmacology, College of Medicine, National Cheng Kung University
Chiung-Chun Huang: Department of Pharmacology, College of Medicine, National Cheng Kung University
Katsuhiko Nishimori: Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University
Kuei-Sen Hsu: Department of Pharmacology, College of Medicine, National Cheng Kung University

DOI: https://doi.org/10.1038/s41467-017-00675-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Oxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of newborn neurons in the dentate gyrus in a non-cell autonomous manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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