Specific features of gastroesophageal reflux disease associated with obesity and overweight

Abstract

Aim. To reveal the specific features of gastroesophageal reflux disease (GERD) associated with obesity and overweight, by investigating the clinical and endoscopic manifestations of the disease, 24-hour pH-metry scores, and leptin levels. Subjects and methods. A total of 131 patients with GERD were examined. The data about complaints and those from life and medical histories were collected; anthropometric measurements and the results of blood biochemical tests, esophagoduodenoscopy (EPDS), and pH-metry were assessed; and the serum levels of leptin and its receptor were estimated. The patients were allocated into a study group (104 obese and/or overweight patients) and a comparison one (27 normal weight people). Results. Waist circumference, hip circumference, and blood glucose levels proved to be statistically significantly higher in the study group (p

Keywords

• obesity
• overweight
• gastroesophageal reflux disease
• leptin
• leptin resistance