Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma

Jessica Tome-Garcia; Parsa Erfani; German Nudelman; Alexander M. Tsankov; Igor Katsyv; Rut Tejero; Bin Zhang; Martin Walsh; Roland H. Friedel; Elena Zaslavsky; Nadejda M. Tsankova

doi:10.1038/s41467-018-06258-2

Nature Communications (Oct 2018)

Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma

Jessica Tome-Garcia,
Parsa Erfani,
German Nudelman,
Alexander M. Tsankov,
Igor Katsyv,
Rut Tejero,
Bin Zhang,
Martin Walsh,
Roland H. Friedel,
Elena Zaslavsky,
Nadejda M. Tsankova

Affiliations

Jessica Tome-Garcia: Department of Pathology, Icahn School of Medicine at Mount Sinai
Parsa Erfani: Department of Pathology, Icahn School of Medicine at Mount Sinai
German Nudelman: Department of Neurology, Icahn School of Medicine at Mount Sinai
Alexander M. Tsankov: Broad Institute of MIT and Harvard
Igor Katsyv: Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Rut Tejero: Department of Neuroscience and The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Bin Zhang: Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Martin Walsh: Department of Pharmacological Sciences, Center for RNA Biology and Medicine
Roland H. Friedel: Department of Neuroscience and The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Elena Zaslavsky: Department of Neurology, Icahn School of Medicine at Mount Sinai
Nadejda M. Tsankova: Department of Pathology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-018-06258-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The intrinsic drivers of glioblastoma (GBM) migration are still poorly understood. Here the authors purify GBM stem cells (GSCs) from patients and profile chromatin accessibility in these cells, identifying TEAD1 as a regulator of migration in human glioblastoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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