Beneficial Oxidative Stress-Related <i>trans</i>-Resveratrol Effects in the Treatment and Prevention of Breast Cancer

Abstract

Resveratrol is one of the most investigated polyphenols for its multiple biological activities and many beneficial effects. These are mainly related to its ability to scavenge free radicals and reduce oxidative stress. Resveratrol has also been shown to have the ability to stimulate the production of antioxidant enzymes, which interact with numerous signaling pathways involved in tumor development, and to possess side effects associated with the use of chemotherapy drugs. In this review article we summarized the main discoveries about the impact resveratrol can have in helping to prevent, as well as adjuvant treating, breast cancer. A brief overview of the primary sources of resveratrol as well as some approaches for improving its bioavailability have been also discussed.

Keywords

• resveratrol
• reactive oxygen species
• breast cancer
• antioxidants
• polyphenols
• oxidative stress