Prothrombin G20210A and Factor V Leiden mutations in ischemic arterial stroke

Abstract

INTRODUCTION: Ischemic stroke remains an important public health problem in all over world. It is wellknown that, some type of genetic mutations such as factor V Leiden and prothrombin G20210A contribute to the risk of ischemic venous stroke. However, the role of those genetic mutations in the risk of arteriel stroke is still controversial. The aim of this study is to investigate the possible association between the genetic mutations such as factor V Leiden and prothrombin G20210A and the risk of arterial ischemic stroke. METHODS: Sixty-three patient with ischemic arterial stroke and 25 age and sex matched controls were included in the study. RESULTS: Prothrombin G20210A mutation, factor V Leiden mutation, hypertention, hyperlipidemia and hyperhomocysteinemia have been found significantly more frequent in patients' group compared to the controls. With the multivariate analysis prothrombin G20210 mutation was found as an independent risk factor for ischemic arterial stroke. Factor V Leiden mutation was not an independent risk factor although it was seen more frequent in the ischemic arteriel stroke group. DISCUSSION AND CONCLUSION: Genetic mutations such as factor V Leiden and especially prothrombin G20210A should be considered as genetic risk factors for stroke. Exploring those mutations in the arteriel stroke cases and the risky groups for stroke might be important to assess risk and manage the disease.

Keywords

• prothrombin g20210a mutation
• factor v leiden mutation
• ischemic arterial stroke