Nature Communications (Feb 2022)
Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain
- Rou-Gang Xie,
- Wen-Guang Chu,
- Da-Lu Liu,
- Xu Wang,
- Sui-Bin Ma,
- Fei Wang,
- Fu-Dong Wang,
- Zhen Lin,
- Wen-Bin Wu,
- Na Lu,
- Ying-Ying Liu,
- Wen-Juan Han,
- Hui Zhang,
- Zhan-Tao Bai,
- San-Jue Hu,
- Hui-Ren Tao,
- Thomas Kuner,
- Xu Zhang,
- Rohini Kuner,
- Sheng-Xi Wu,
- Ceng Luo
Affiliations
- Rou-Gang Xie
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Wen-Guang Chu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Da-Lu Liu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Xu Wang
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Sui-Bin Ma
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Fei Wang
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Fu-Dong Wang
- Class 2015, The Fourth Squadron of the Fourth Regiment, School of Basic Medicine, Fourth Military Medical University
- Zhen Lin
- Class 2013, The Fourth Squadron of the Second Regiment, School of Basic Medicine, Fourth Military Medical University
- Wen-Bin Wu
- Class 2015, The Fourth Squadron of the Fourth Regiment, School of Basic Medicine, Fourth Military Medical University
- Na Lu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Ying-Ying Liu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Wen-Juan Han
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Hui Zhang
- Department of Health Statistics, School of Preventive Medicine, Fourth Military Medical University
- Zhan-Tao Bai
- Research Center for Resource Polypeptide Drugs & College of Life Sciences, Yanan University
- San-Jue Hu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Hui-Ren Tao
- Department of Spine Surgery, Shenzhen University General Hospital
- Thomas Kuner
- Institute for Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307
- Xu Zhang
- Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Rohini Kuner
- Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366
- Sheng-Xi Wu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Ceng Luo
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- DOI
- https://doi.org/10.1038/s41467-022-28429-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term potentiation and chronic pain. Here, the authors show that also presynaptic NMDARs in spinal nociceptor terminals modulate synaptic transmission in a nociceptive tone-dependent manner.
