F1000Research (2020-12-01)

Cyclic stroke mortality variations follow sunspot patterns [version 2; peer review: 2 approved]

  • Stella Geronikolou,
  • Alexandros Leontitsis,
  • Vasilis Petropoulos,
  • Constantinos Davos,
  • Dennis Cokkinos,
  • George Chrousos

Journal volume & issue
Vol. 9


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Background: Mapping time-structures is a burgeoning scientific field enriching the (P4) medicine models. Local evidence in Mediterranean populations is underinvestigated. Methods: The Censused stroke-related death events (D) in the largest East-Mediterranean port (Piraeus), during (1985-1989), when local population had diet (low fat/sugar, proteins and vegetables/fruits daily, and pure olive oil almost exclusively) and genetic homogeneity-later interrupted by the immigration into Greece in 1990; and Sunspot numbers were indexed by Wolf numbers (Rz) (1944-2004), and evaluated using Fast Fourier Analysis and Singular Spectrum Analysis in MATLAB. Results: D were turned with fluctuations >35% in Rz. A non-anthropogenic 6.8 days cycle was recognized. Conclusions: This study may be taken into consideration in future public health planning and chronotherapy evaluations.