Deciphering Gorilla gorilla gorilla immunoglobulin loci in multiple genome assemblies and enrichment of IMGT resources

Chahrazed Debbagh; Géraldine Folch; Joumana Jabado-Michaloud; Véronique Giudicelli; Sofia Kossida; Sofia Kossida

doi:10.3389/fimmu.2024.1475003

Frontiers in Immunology (Oct 2024)

Deciphering Gorilla gorilla gorilla immunoglobulin loci in multiple genome assemblies and enrichment of IMGT resources

Chahrazed Debbagh,
Géraldine Folch,
Joumana Jabado-Michaloud,
Véronique Giudicelli,
Sofia Kossida,
Sofia Kossida

Affiliations

Chahrazed Debbagh: The International ImMunoGeneTics® Information System (IMGT®), Institute of Human Genetics (IGH), National Center for Scientific Research (CNRS), University of Montpellier (UM), Montpellier, France
Géraldine Folch: The International ImMunoGeneTics® Information System (IMGT®), Institute of Human Genetics (IGH), National Center for Scientific Research (CNRS), University of Montpellier (UM), Montpellier, France
Joumana Jabado-Michaloud: The International ImMunoGeneTics® Information System (IMGT®), Institute of Human Genetics (IGH), National Center for Scientific Research (CNRS), University of Montpellier (UM), Montpellier, France
Véronique Giudicelli: The International ImMunoGeneTics® Information System (IMGT®), Institute of Human Genetics (IGH), National Center for Scientific Research (CNRS), University of Montpellier (UM), Montpellier, France
Sofia Kossida: The International ImMunoGeneTics® Information System (IMGT®), Institute of Human Genetics (IGH), National Center for Scientific Research (CNRS), University of Montpellier (UM), Montpellier, France
Sofia Kossida: Institut Universitaire de France (IUF), Paris, France

DOI: https://doi.org/10.3389/fimmu.2024.1475003
Journal volume & issue: Vol. 15

Abstract

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Through the analysis of immunoglobulin genes at the IGH, IGK, and IGL loci from four Gorilla gorilla gorilla genome assemblies, IMGT® provides an in-depth overview of these loci and their individual variations in a species closely related to humans. The similarity between gorilla and human IG gene organization allowed the assignment of gorilla IG gene names based on their human counterparts. This study revealed significant findings, including variability in the IGH locus, the presence of known and new copy number variations (CNVs), and the accurate estimation of IGHG genes. The IGK locus displayed remarkable homogeneity and lacked the gene duplication seen in humans, while the IGL locus showed a previously unconfirmed CNV in the J-C cluster. The curated data from these analyses, available on the IMGT website, enhance our understanding of gorilla immunogenetics and provide valuable insights into primate evolution.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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