Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

Rituraj Pal; Michela Palmieri; Arindam Chaudhury; Tiemo Jürgen Klisch; Alberto di Ronza; Joel R. Neilson; George G. Rodney; Marco Sardiello

doi:10.1038/s41467-018-06844-4

Nature Communications (Oct 2018)

Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

Rituraj Pal,
Michela Palmieri,
Arindam Chaudhury,
Tiemo Jürgen Klisch,
Alberto di Ronza,
Joel R. Neilson,
George G. Rodney,
Marco Sardiello

Affiliations

Rituraj Pal: Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Michela Palmieri: Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Arindam Chaudhury: Department of Molecular Physiology and Biophysics, Baylor College of Medicine
Tiemo Jürgen Klisch: Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Alberto di Ronza: Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Joel R. Neilson: Department of Molecular Physiology and Biophysics, Baylor College of Medicine
George G. Rodney: Department of Molecular Physiology and Biophysics, Baylor College of Medicine
Marco Sardiello: Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital

DOI: https://doi.org/10.1038/s41467-018-06844-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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The growth-promoting activity of mTORC1 is regulated by amino acid availability via the Rag GTPases. Here, the authors demonstrate Src-dependent control of cell size and autophagy through disruption of the Rag GTPase–GATOR1 complex and mTORC1 activation at the lysosomal surface.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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