Heterometallic ZnHoMOF as a Dual-Responsive Luminescence Sensor for Efficient Detection of Hippuric Acid Biomarker and Nitrofuran Antibiotics
Jingrui Yin,
Wenqian Li,
Wencui Li,
Liying Liu,
Dongsheng Zhao,
Xin Liu,
Tuoping Hu,
Liming Fan
Affiliations
Jingrui Yin
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Wenqian Li
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Wencui Li
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Liying Liu
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Dongsheng Zhao
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Xin Liu
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Tuoping Hu
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Liming Fan
Shanxi Key Laboratory of Advanced Carbon Electrode Materials, Shanxi Coal Mine Water Treatment Technology Innovation Center, School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
Developing efficient and sensitive MOF-based luminescence sensors for bioactive molecule detection is of great significance and remains a challenge. Benefiting from favorable chemical and thermal stability, as well as excellent luminescence performance, a porous Zn(II)Ho(III) heterometallic–organic framework (ZnHoMOF) was selected here as a bifunctional luminescence sensor for the early diagnosis of a toluene exposure biomarker of hippuric acid (HA) through “turn-on” luminescence enhancing response and the daily monitoring of NFT/NFZ antibiotics through “turn-off” quenching effects in aqueous media with high sensitivity, acceptable selectivity, good anti-interference, exceptional recyclability performance, and low detection limits (LODs) of 0.7 ppm for HA, 0.04 ppm for NFT, and 0.05 ppm for NFZ. Moreover, the developed sensor was employed to quantify HA in diluted urine samples and NFT/NFZ in natural river water with satisfactory results. In addition, the sensing mechanisms of ZnHoMOF as a dual-response chemosensor in efficient detection of HA and NFT/NFZ antibiotics were conducted from the view of photo-induced electron transfer (PET), as well as inner filter effects (IFEs), with the help of time-dependent density functional theory (TD-DFT) and spectral overlap experiments.
