Zhongguo quanke yixue (Feb 2023)

Sex-specific Analysis of Influencing Factors for the Association between Baseline Serum Uric Acid and Two-year Outcome after First Acute Ischemic Stroke

  • YAO Huihui, SHU Lin, YAO Linli, LI Sha, YANG Xiaotong, LI Yunchun

DOI
https://doi.org/10.12114/j.issn.1007-9572.2022.0582
Journal volume & issue
Vol. 26, no. 05
pp. 557 – 562

Abstract

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Background The level of serum uric acid (SUA) has recently been proven to be associated with outcomes in patients with acute ischemic stroke (AIS) , but whether the association is still controversial. Objective To explore the relationship of baseline SUA level with two-year recurrence and all-cause mortality after first AIS. Methods This retrospective study was conducted with a cohort of inpatients with first AIS treated in Department of Neurology, University of Hong Kong-Shenzhen Hospital from January 1, 2018 to December 31, 2019. The general information, biochemical indicators, and two-year adverse outcome (recurrence and all-cause mortality) after first AIS were collected and a follow up until December 31, 2021. Logistic regression analysis was used to explore the relationship of adverse outcome with quartile of baseline SUA levels〔Q1 group (n=129) , Q2 group (n=129) , Q3 group (n=128) , Q4 group (n=127) 〕 by sex. Results Univariate Logistic regression analysis showed that advanced age, history of diabetes, history of chronic renal insufficiency, high fasting blood glucose and triglyceride levels were risk factors for two-year recurrence and all-cause mortality after first AIS in male patients (P<0.05) . And advanced age and history of diabetes were risk factors for two-year recurrence and all-cause mortality after first AIS in female patients (P<0.05) . Multivariate Logistic regression analysis showed that the risk of two-year recurrence and all-cause mortality in males in Q4 group was lower than that of those in Q1 group〔OR=0.187, 95%CI (0.035, 0.990) , P<0.05〕 after adjusting for various confounding factors. Conclusion Higher baseline level of SUA was associated with lower two-year recurrence and all-cause mortality in male patients after first AIS compared to lower baseline level SUA. while intermediate baseline level of SUA was not associated with .

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