mBio (Apr 2021)

Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits

  • Joshua M. Wang,
  • Andrew L. Woodruff,
  • Matthew J. Dunn,
  • Robert J. Fillinger,
  • Richard J. Bennett,
  • Matthew Z. Anderson

DOI
https://doi.org/10.1128/mBio.00586-21
Journal volume & issue
Vol. 12, no. 2

Abstract

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Infectious fungal species are often treated uniformly despite clear evidence of genotypic and phenotypic heterogeneity being widespread across strains. Identifying the genetic basis for this phenotypic diversity is extremely challenging because of the tens or hundreds of thousands of variants that may distinguish two strains.