Pyroptosis and Its Regulation in Diabetic Cardiomyopathy

Yafang Lu; Yaqiong Lu; Jun Meng; Zuo Wang

doi:10.3389/fphys.2021.791848

Frontiers in Physiology (Jan 2022)

Pyroptosis and Its Regulation in Diabetic Cardiomyopathy

Yafang Lu,
Yaqiong Lu,
Jun Meng,
Zuo Wang

Affiliations

Yafang Lu: Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, China
Yaqiong Lu: Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, China
Jun Meng: Functional Department, The First Affiliated Hospital, University of South China, Hengyang, China
Zuo Wang: Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, China

DOI: https://doi.org/10.3389/fphys.2021.791848
Journal volume & issue: Vol. 12

Abstract

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Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM. This review summarizes the regulatory mechanisms of pyroptosis in DbCM, including NOD-like receptor3, AIM2 inflammasome, long non-coding RNAs, microRNAs, circular RNA, autophagy, and some drugs.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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