Brain network construction and analysis for patients with mild cognitive impairment and Alzheimer's disease based on a highly‐available nodes approach

Abstract

Abstract Introduction Using brain network and graph theory methods to analyze the Alzheimer's disease (AD) and mild cognitive impairment (MCI) abnormal brain function is more and more popular. Plenty of potential methods have been proposed, but the representative signal of each brain region in these methods remains poor performance. Methods We propose a highly‐available nodes approach for constructing brain network of patients with MCI and AD. With resting‐state functional magnetic resonance imaging (rs‐fMRI) data of 84 AD subjects, 81 MCI subjects, and 82 normal control (NC) subjects from the Alzheimer's Disease Neuroimaging Initiative Database, we construct connected weighted brain networks based on the different sparsity and minimum spanning tree. Support Vector Machine of Radial Basis Function kernel was selected as classifier. Results Accuracies of 74.09% and 77.58% in classification of MCI and AD from NC, respectively. We also performed a hub node analysis and found 18 significant brain regions were identified as hub nodes. Conclusions The findings of this study provide insights for helping understanding the progress of the AD. The proposed method highlights the effectively representative time series of brain regions of rs‐fMRI data for construction and topology analysis brain network.

Keywords

• Alzheimer's disease
• mild cognitive impairment
• network graph
• resting‐state functional magnetic resonance imaging
• support vector machine