Frontiers in Immunology (Mar 2019)
Yersinia pestis Interacts With SIGNR1 (CD209b) for Promoting Host Dissemination and Infection
- Kun Yang,
- Kun Yang,
- Yingxia He,
- Chae Gyu Park,
- Young Sun Kang,
- Pei Zhang,
- Yanping Han,
- Yujun Cui,
- Silvia Bulgheresi,
- Andrey P. Anisimov,
- Svetlana V. Dentovskaya,
- Xiaoling Ying,
- Lingyu Jiang,
- Honghui Ding,
- Olivia Adhiambo Njiri,
- Olivia Adhiambo Njiri,
- Shusheng Zhang,
- Guoxing Zheng,
- Lianxu Xia,
- Biao Kan,
- Xin Wang,
- Huaiqi Jing,
- Meiying Yan,
- Wei Li,
- Yuanzhi Wang,
- Xiding Xiamu,
- Gang Chen,
- Ding Ma,
- Sara Schesser Bartra,
- Gregory V. Plano,
- John D. Klena,
- Ruifu Yang,
- Mikael Skurnik,
- Tie Chen,
- Tie Chen
Affiliations
- Kun Yang
- Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Kun Yang
- Department of Pathogen Biology and Immunology, Shihezi University School of Medicine, Shihezi, China
- Yingxia He
- Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Chae Gyu Park
- Laboratory of Immunology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea
- Young Sun Kang
- Laboratory of Immunology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea
- Pei Zhang
- Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States
- Yanping Han
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
- Yujun Cui
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
- Silvia Bulgheresi
- Department of Ecogenomics and Systems Biology, University of Vienna, Vienna, Austria
- Andrey P. Anisimov
- State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia
- Svetlana V. Dentovskaya
- State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia
- Xiaoling Ying
- Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Lingyu Jiang
- Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Honghui Ding
- Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Olivia Adhiambo Njiri
- Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Olivia Adhiambo Njiri
- Department of Biological Sciences, Faculty of Science, Technology and Engineering, Chuka University, Chuka, Kenya
- Shusheng Zhang
- Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States
- Guoxing Zheng
- Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States
- Lianxu Xia
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Biao Kan
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Xin Wang
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Huaiqi Jing
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Meiying Yan
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Wei Li
- National Institute for Communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- Yuanzhi Wang
- Department of Pathogen Biology and Immunology, Shihezi University School of Medicine, Shihezi, China
- Xiding Xiamu
- Department of Pathogen Biology and Immunology, Shihezi University School of Medicine, Shihezi, China
- Gang Chen
- 0Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Ding Ma
- 1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Sara Schesser Bartra
- 2Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States
- Gregory V. Plano
- 2Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States
- John D. Klena
- 3School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
- Ruifu Yang
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
- Mikael Skurnik
- 4Department of Bacteriology and Immunology, Haartman Institute, Helsinki University Central Hospital Laboratory Diagnostics, University of Helsinki, Helsinki, Finland
- Tie Chen
- Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Tie Chen
- Department of Pathogen Biology and Immunology, Shihezi University School of Medicine, Shihezi, China
- DOI
- https://doi.org/10.3389/fimmu.2019.00096
- Journal volume & issue
-
Vol. 10
Abstract
Yersinia pestis, a Gram-negative bacterium and the etiologic agent of plague, has evolved from Yersinia pseudotuberculosis, a cause of a mild enteric disease. However, the molecular and biological mechanisms of how Y. pseudotuberculosis evolved to such a remarkably virulent pathogen, Y. pestis, are not clear. The ability to initiate a rapid bacterial dissemination is a characteristic hallmark of Y. pestis infection. A distinguishing characteristic between the two Yersinia species is that Y. pseudotuberculosis strains possess an O-antigen of lipopolysaccharide (LPS) while Y. pestis has lost the O-antigen during evolution and therefore exposes its core LPS. In this study, we showed that Y. pestis utilizes its core LPS to interact with SIGNR1 (CD209b), a C-type lectin receptor on antigen presenting cells (APCs), leading to bacterial dissemination to lymph nodes, spleen and liver, and the initiation of a systemic infection. We therefore propose that the loss of O-antigen represents a critical step in the evolution of Y. pseudotuberculosis into Y. pestis in terms of hijacking APCs, promoting bacterial dissemination and causing the plague.
Keywords
- Yersinia pestis
- SIGNR1 (CD209b)
- macrophages
- dendritic cells (DCs)
- antigen presenting cells (APCs)
- core lipopolysaccharide/lipooligosaccharides (core LPS/LOS)
