Nature Communications (Apr 2021)
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection
- Rachel Wheatley,
- Julio Diaz Caballero,
- Natalia Kapel,
- Fien H. R. de Winter,
- Pramod Jangir,
- Angus Quinn,
- Ester del Barrio-Tofiño,
- Carla López-Causapé,
- Jessica Hedge,
- Gabriel Torrens,
- Thomas Van der Schalk,
- Basil Britto Xavier,
- Felipe Fernández-Cuenca,
- Angel Arenzana,
- Claudia Recanatini,
- Leen Timbermont,
- Frangiscos Sifakis,
- Alexey Ruzin,
- Omar Ali,
- Christine Lammens,
- Herman Goossens,
- Jan Kluytmans,
- Samir Kumar-Singh,
- Antonio Oliver,
- Surbhi Malhotra-Kumar,
- Craig MacLean
Affiliations
- Rachel Wheatley
- University of Oxford, Department of Zoology
- Julio Diaz Caballero
- University of Oxford, Department of Zoology
- Natalia Kapel
- University of Oxford, Department of Zoology
- Fien H. R. de Winter
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Pramod Jangir
- University of Oxford, Department of Zoology
- Angus Quinn
- University of Oxford, Department of Zoology
- Ester del Barrio-Tofiño
- Hospital Universitario Son Espases
- Carla López-Causapé
- Hospital Universitario Son Espases
- Jessica Hedge
- University of Oxford, Department of Zoology
- Gabriel Torrens
- Hospital Universitario Son Espases
- Thomas Van der Schalk
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Basil Britto Xavier
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Felipe Fernández-Cuenca
- Departamento de Medicina, Universidad de Sevilla
- Angel Arenzana
- Departamento de Medicina, Universidad de Sevilla
- Claudia Recanatini
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
- Leen Timbermont
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Frangiscos Sifakis
- Boehringer Ingelheim Pharmaceuticals, Inc
- Alexey Ruzin
- Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca
- Omar Ali
- Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca
- Christine Lammens
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Herman Goossens
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Jan Kluytmans
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
- Samir Kumar-Singh
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Antonio Oliver
- Hospital Universitario Son Espases
- Surbhi Malhotra-Kumar
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp
- Craig MacLean
- University of Oxford, Department of Zoology
- DOI
- https://doi.org/10.1038/s41467-021-22814-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Here, following a patient with severe acute Pseudomonas aeruginosa infection, the authors combine comprehensive isolate characterization from lung and gut samples (>100 isolates) and patient clinical data to provide insights into bacterial responses to antibiotic therapy.
