Journal of the Serbian Chemical Society (Jan 1999)

The synthesis of a small library of prospective growth hormone secretagogues

  • Pejović Vojislav,
  • Šoškić Vukić,
  • Joksimović Jelena

DOI
https://doi.org/10.2298/jsc9910571p
Journal volume & issue
Vol. 64, no. 10
pp. 571 – 576

Abstract

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Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues. For this purpose seven building blocks of tBoc- and Fmoc-protected amino acids was used. In this way, a small, tripeptoid library on polyethylene glycolmonomethyl ether 5000 (PEG 5000) as a soluble support was obtained. The library was screened by a new, simple system, based on polyclonal rabbit antiserum raised against "GH secretagogue pharmacophore" of a known growth hormone secretagogue GHRP-6 (Hexarelin®) and the most promising GH secretagogue candidate was selected.

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