Frontiers in Oncology (Jul 2013)

PML, SUMOylation and senescence

  • Hugues eDe Thé,
  • Hugues eDe Thé,
  • Hugues eDe Thé,
  • Hugues eDe Thé,
  • Hugues eDe Thé,
  • Lisa eIvanschitz,
  • Lisa eIvanschitz,
  • Lisa eIvanschitz,
  • Morgane eLe Bras,
  • Morgane eLe Bras,
  • Morgane eLe Bras

DOI
https://doi.org/10.3389/fonc.2013.00171
Journal volume & issue
Vol. 3

Abstract

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Since its discovery, 25 years ago, PML has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation... there are multiple PML-related issues. Here we review the reciprocal interactions between PML, senescence and SUMOylation, notably in the context of cellular transformation.

Keywords