Journal of Comparative Effectiveness Research (Aug 2023)

Cost–consequence analysis of ofatumumab for the treatment of relapsing-remitting multiple sclerosis in Canada

  • Virender Bhan,
  • Fraser Clift,
  • Moogeh Baharnoori,
  • Kimberly Thomas,
  • Barkha P Patel,
  • Francois Blanchette,
  • Nicholas Adlard,
  • Umakanth Vudumula,
  • Kapil Gudala,
  • Nikkita Dutta,
  • Daniel Grima,
  • Soukaina Mouallif,
  • Fatine Farhane

DOI
https://doi.org/10.57264/cer-2022-0175
Journal volume & issue
Vol. 12, no. 9

Abstract

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Aim: The costs and consequences of initial and delayed ofatumumab treatment were evaluated in relapsing-remitting multiple sclerosis with active disease in Canada. Materials & methods: A Markov cohort model was used (10-year horizon, annual cycle length, 1.5% discounting). Scenario analyses examined ofatumumab as first-line treatment versus 3 and 5 years following switch from commonly used first-line therapies. Results: Ofatumumab resulted in improvements in clinical outcomes (relapses and disease progression) and productivity (employment and full-time work), and reduction of economic burden (administration, monitoring and non-drug costs) that were comparable to other high-efficacy therapies (ocrelizumab, cladribine and natalizumab). Switching to ofatumumab earlier in the disease course may improve these outcomes. Conclusion: Results highlight the value of a high-efficacy therapy such as ofatumumab as initial treatment (i.e., first-line) in newly diagnosed relapsing-remitting multiple sclerosis patients with active disease.

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