Journal of Diabetes (May 2025)
Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study
- Lei Xi,
- Li Li,
- Songbo Fu,
- Yuancheng Dai,
- Juan Shi,
- Yanmei Yu,
- Ying Peng,
- Hongmei Qiu,
- Jinsong Kuang,
- Hongyun Lu,
- Huige Shao,
- Chunlei Yuan,
- Xiaohu Wang,
- Ping Zhang,
- Sheli Li,
- Yanhui Pan,
- Ling Hu,
- Zhigang Zhao,
- Yunxia Chen,
- Jian Kuang,
- Yi Shu,
- Jinhua Qian,
- Qibin Mao,
- Jieji Zhang,
- Yan Liu,
- Hong Yang,
- Zhaoli Yan,
- Weici Xie,
- Qian Zhang,
- Ping Zhang,
- Hongji Wu,
- Ling Gao,
- Yongjun Jin,
- Ning Xu,
- Chaoyang Xu,
- Xiaohui Sun,
- Zhimin Feng,
- Qing Zhang,
- Lin Li,
- Guang Ning,
- Yifei Zhang,
- Yanan Cao,
- Weiqing Wang
Affiliations
- Lei Xi
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Li Li
- Department of Endocrinology The First Affiliated Hospital of Ningbo University Ningbo China
- Songbo Fu
- Department of Endocrinology The First Hospital of Lanzhou University Lanzhou China
- Yuancheng Dai
- Department of Internal Medicine of Traditional Chinese Medicine Sheyang Diabetes Hospital Yancheng China
- Juan Shi
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Yanmei Yu
- Department of Endocrinology Mudanjiang Cardiovascular Hospital Mudanjiang China
- Ying Peng
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Hongmei Qiu
- Department of Endocrinology and Metabolism People's Hospital of Yuxi City (The Sixth Affiliated Hospital of Kunming Medical University) Yuxi China
- Jinsong Kuang
- Department of Endocrinology and Metabolism Shenyang Fourth People Hospital Shenyang China
- Hongyun Lu
- Department of Endocrinology and Metabolism, Zhuhai Clinical Medical College Affiliated With Jinan University Zhuhai People's Hospital Zhuhai China
- Huige Shao
- Department of Endocrinology Changsha Central Hospital Changsha China
- Chunlei Yuan
- Department of Endocrinology Shandong Health Zibo Hospital Zibo China
- Xiaohu Wang
- Department of Endocrinology and Metabolism Anyang People's Hospital Anyang China
- Ping Zhang
- Department of Endocrinology The First People's Hospital of YuLin Yulin China
- Sheli Li
- Department of Endocrinology and Metabolism Yan'an University Affiliated Hospital Yan'an China
- Yanhui Pan
- Department of Endocrinology Qixia City People's Hospital Qixia China
- Ling Hu
- Department of Endocrinology The Third Affiliated Hospital of Nanchang University (The First Hospital of Nanchang) Nanchang China
- Zhigang Zhao
- Department of Endocrinology Yihe Hospital Zhengzhou China
- Yunxia Chen
- Department of Endocrinology and Metabolism Cangzhou People's Hospital Cangzhou China
- Jian Kuang
- Department of Endocrinology, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China
- Yi Shu
- Department of Endocrinology, The Sixth Affiliated Hospital, School of Medicine South China University of Technology Foshan China
- Jinhua Qian
- Department of Endocrine and Metabolic Diseases The People's Hospital of Pizhou Pizhou China
- Qibin Mao
- Department of Endocrinology and Metabolism Shaoxing Second Hospital Shaoxing China
- Jieji Zhang
- Department of Endocrinology Fenghua District Traditional Chinese Medicine Hospital of Ningbo Ningbo China
- Yan Liu
- Department of Endocrinology The Third People's Hospital of Datong Datong China
- Hong Yang
- Department of Endocrinology Ruian People's Hospital Ruian China
- Zhaoli Yan
- Department of Endocrinology The Affiliated Hospital of Inner Mongolia Medical University Hohhot China
- Weici Xie
- Department of Endocrinology The No. 1 General Hospital in Tian Men Tianmen China
- Qian Zhang
- Department of Endocrinology The Second Affiliated Hospital of Guizhou Medical University Kaili China
- Ping Zhang
- Department of Endocrinology The Second Affiliated Hospital of Dalian Medical University Dalian China
- Hongji Wu
- Department of Endocrinology People's Hospital of Putuo District Zhoushan China
- Ling Gao
- Department of Endocrinology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science Xiangyang China
- Yongjun Jin
- Department of Endocrinology and Metabolism Yantai Affiliated Hospital of Binzhou Medical University Yantai China
- Ning Xu
- Department of Endocrinology The First People's Hospital of Lianyungang Lianyungang China
- Chaoyang Xu
- Department of Endocrinology Jiangsu Shengze Hospital Suzhou China
- Xiaohui Sun
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Zhimin Feng
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Qing Zhang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Lin Li
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Guang Ning
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Yifei Zhang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Yanan Cao
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Weiqing Wang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- DOI
- https://doi.org/10.1111/1753-0407.70095
- Journal volume & issue
-
Vol. 17,
no. 5
pp. n/a – n/a
Abstract
ABSTRACT Background To determine the associations between sleep phenotypes and the risks of specific obesity types and weight gain in patients with type 2 diabetes (T2D), especially in different genetic risk groups. Materials and Methods We conducted a prospective study involving 58 890 participants. Sleep and napping were assessed according to the standardized questionnaire. General and abdominal obesity were defined by BMI or visceral fat area (VFA), respectively. Multivariable Cox regression, stratified, and joint analysis were performed to explore potential correlations. Furthermore, mediation models were constructed to figure out the mediating role of metabolic factors (blood pressure, UACR, and HbA1c). Results During a median 3.05‐year follow‐up period, short sleep increased the risk of obesity (HR 1.42, 95% CI 1.17–1.71; 1.33, 1.08–1.65) and weight gain (1.21, 1.09–1.34; 1.17, 1.06–1.29), while long sleep and napping were unrelated to abdominal obesity and weight gain. Mediation analysis showed that systolic blood pressure, UACR, and HbA1c mediated the statistical association between night sleep duration and general obesity with proportions (%) of 7.9, 1.8, and 8.8, respectively. Joint analysis showed both sleep and napping groups had no significance among the low genetic risk group, while long napping, short sleep, and long sleep increased the risk of general obesity in medium to high risk patients. Conclusions Short sleep, long sleep, and long napping increased the risk of general obesity and BMI‐defined weight gain, and were more pronounced in the medium to high genetic risk group. Napping was unrelated to abdominal obesity. Metabolic factors partially explain the mechanism between sleep and obesity.
Keywords
