Breast Cancer: Targets and Therapy (Aug 2021)
Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation
Abstract
Jamie Smith,1 Charles Leonard,1 Dennis L Carter,2 Shannon Tole1 1Rocky Mountain Cancer Centers Littleton, Denver, CO, USA; 2Rocky Mountain Cancer Centers Aurora, Denver, Co, USACorrespondence: Jamie SmithRocky Mountain Cancer Centers Littleton, 790 Fillmore St., Denver, Co, 80206, USATel +1 303-304-1187Email [email protected]: To report a primary objective clinical outcome of ipsilateral breast cancer recurrence following accelerated partial breast irradiation (APBI) with N0(i+) (single tumor cells or clusters 2 mm. All enrolled patients presented in this report had sentinel lymph node examinations. Clinical outcomes of ipsilateral breast, axillary and combined regional (breast or axillary) recurrences were analyzed.Results: Median follow-up for all patients was 5 years (1– 8 years). No patient experienced either ipsilateral breast or axillary recurrence.Conclusion: There has been scarce information/reporting of the treatment of patients with cytokeratin positive individual tumor cells N0(i+) with APBI. The authors have presented data which suggest that the successful outcomes of these patients might warrant further study.Keywords: breast sentinel nodes, breast conservation therapy
