IgG4-related disease: what do we know after 20 years

Abstract

IgG4-related disease is immunomediated fibroinflammatory condition, characterized by tumefective lesions in different organs with distinctive pathomorphological features and IgG4 hypersecretion in serum and tissues in the majority of patients. IgG4-RD has been established as a separate clinical in the early 2000s. In the review we focus on the evolution of views on ethiopathogenesis of the disease, therapeutic and diagnostic options and classification of the disease.

Keywords

• igg4-related disease
• diagnostic criteria
• classification criteria
• pathogenesis
• сd4+ t cytotoxic cells
• plasmabalsts
• malignancy
• lymphoma
• allergy
• abatacept
• rituximab