The emerging role of RNA N6-methyladenosine methylation in breast cancer

Fangchao Zheng; Feng Du; Jiuda Zhao; Xue Wang; Yiran Si; Peng Jin; Haili Qian; Binghe Xu; Peng Yuan

doi:10.1186/s40364-021-00295-8

Biomarker Research (May 2021)

The emerging role of RNA N6-methyladenosine methylation in breast cancer

Fangchao Zheng,
Feng Du,
Jiuda Zhao,
Xue Wang,
Yiran Si,
Peng Jin,
Haili Qian,
Binghe Xu,
Peng Yuan

Affiliations

Fangchao Zheng: Department of Medical Oncology, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Feng Du: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), The VIPII Gastrointestinal Cancer Division of Medical Department, Peking University Cancer Hospital and Institute
Jiuda Zhao: Breast Disease Diagnosis and Treatment Center, Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University
Xue Wang: Department of VIP Medical Services, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yiran Si: Department of Medical Oncology, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Peng Jin: Department of Surgery, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Haili Qian: State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College
Binghe Xu: Department of Medical Oncology, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Peng Yuan: Department of Medical Oncology, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

DOI: https://doi.org/10.1186/s40364-021-00295-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Abstract N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.

Published in Biomarker Research

ISSN: 2050-7771 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://biomarkerres.biomedcentral.com/

About the journal

Abstract

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