The Idea of Kidney Tonifying Therapy for Spermatogenesis Disorder in Type 2 Diabetes Mellitus Based on the Hypothalamic-pituitary-gonadal Axis

Abstract

Diabetic hyperglycemia in males is a significant contributing factor to the development of spermatogenesis disorder. The hypothalamic-pituitary-gonadal (HPG) axis serves as a crucial center for autonomic sexual function and the neuroendocrine network within the human body. It dominates physiological prominence in human reproduction, growth, and development, while also being susceptible to hyperglycemia, which is one of the key mechanisms in the development of spermatogenic disorder in type 2 diabetes mellitus (T2DM). This mechanism involves kidney deficiency, which is a common etiology and pathogenesis of both spermatogenesis disorder and T2DM. The kidney storing essence, which encompasses the functions of "dominating reproduction, manufacturing marrow to fill up the brain" bears similarities to the HPG axis. Kidney tonifying therapy can regulate and improve the function of HPG axis, thereby establishing a theoretical basis for the use of kidney tonification therapy in the treatment of spermatogenesis disorder in T2DM. The traditional formula of tonifying the kidney can serve as a complementary treatment for both DM and spermatogenesis disorder. This approach offers a conceptual framework and methodology for the prevention and treatment of T2DM-induced infertility through kidney tonification.

Keywords

• hypothalamo-hypophyseal system|diabetes mellitus, type 2|dyszoospermia|reinforcing kidney|theoretical discussion