GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study

Abstract

Honge Li,1,* Raorao Wang,1,* Xueyan Wei,1,* Chunyan Zhang,1 Wenhui Pei,1 Xuhui Zhang,2 Zhen Yang,1 Zhi Li,3 Yuhuan Zhang,1 Yanli Shi,1 Yunchao Wang,4 Xinhua Wang1 1Institute of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu, People’s Republic of China; 2Department of Respiratory Medicine, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu, People’s Republic of China; 3The State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Institute of Public Health, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 4Institute of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunchao Wang, Institute of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, 730000, People’s Republic of China, Tel [phone], Email [email protected] Xinhua Wang, Institute of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu, 730000, People’s Republic of China, Tel [phone], Email [email protected]: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory ailment influenced by a blend of genetic and environmental factors. Inflammatory response and an imbalance in oxidative-antioxidant mechanisms constitute the primary pathogenesis of COPD. Glutathione S-transferase P1(GSTP1) plays a pivotal role as an antioxidant enzyme in regulating oxidative-antioxidant responses in the pulmonary system. The activation of the NOD-like receptor thermal protein domain (NLRP3) inflammatory vesicle can trigger an inflammatory response. Several investigations have implicated GSTP1 and NLRP3 in the progression of COPD; nonetheless, there remains debate regarding this mechanism.Methods: Employing a case-control study design, 312 individuals diagnosed with COPD and 314 healthy controls were recruited from Gansu Province to evaluate the correlation between GSTP1 (rs4147581C>G and rs1695A>G) and NLRP3 (rs3806265T>C and rs10754558G>C) polymorphisms and the susceptibility to COPD.Results: The presence of the GSTP1 rs4147581G allele substantially elevated the susceptibility to COPD (CGvs.CC:OR=3.11,95% CI=1.961– 4.935, PG and rs10754558G>C polymorphisms and COPD susceptibility (P> 0.05).Conclusion: In summary, this study ascertained that the GSTP1 rs4147581C>G polymorphism is associated with increased COPD susceptibility, with the G allele elevating the risk of COPD. Similarly, the NLRP3 rs3806265T>C polymorphism is linked to elevated COPD susceptibility, with the T allele heightening the risk of COPD.Keywords: chronic obstructive pulmonary disease, GSTP1, NLRP3, polymorphism

Keywords

• chronic obstructive pulmonary disease
• gstp1
• nlrp3
• polymorphism