Einstein (São Paulo) ()

Comparative study of the results from conventional cervico-vaginal oncotic cytology and liquid-based cytology

  • Sueli Aparecida Batista Stabile,
  • Dilson Henrique Ramos Evangelista,
  • Valdely Helena Talamonte,
  • Umberto Gazi Lippi,
  • Reginaldo Guedes Coelho Lopes

DOI
https://doi.org/10.1590/s1679-45082012000400013
Journal volume & issue
Vol. 10, no. 4
pp. 466 – 472

Abstract

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OBJECTIVE: To compare two oncotic cervical cytology techniques, the conventional and the liquid-based cytology, in low risk patients for uterine cervical cancer. METHODS: Comparative prospective study with 100 patients who came to their annual gynecological exam, and were submitted simultaneously to both techniques. We used the McNemar test, with a significance level of p<0.05 to compare the results obtained related to adequacy of the smear quality, descriptive diagnosis prevalence, guided biopsy confirmation and histology. RESULTS: Adequacy of the smear was similar for both methods. The quality with squamocolumnar junction in 93% of conventional cytology and in 84% of the liquid-based cytology had statistical significance. As for the diagnosis of atypical cells they were detected in 3% of conventional cytology and in 10% of liquidbased cytology (p=0.06). Atypical squamous cells of undetermined significance were the most prevalent abnormality. The liquid-based cytology performance was better when compared with colposcopy (guided biopsy), presenting sensitivity of 66.7% and specificity of 100%. There was no cytological and histological concordance for the conventional cytology. CONCLUSIONS: Liquid-based cytology had a better performance to diagnose atypical cells and the cytohistological concordance was higher than in the conventional cytology.

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