Biomarker Research (Jun 2021)

Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

  • Fang Lv,
  • Xueying Wu,
  • Jin Song,
  • Pan Wang,
  • Shucheng Ren,
  • Wei Guo,
  • Qi Xue,
  • Henghui Zhang,
  • Jun Zhao

DOI
https://doi.org/10.1186/s40364-021-00287-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 4

Abstract

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Abstract It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.

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